Well hell, I misread what he was asking. I thought he was asking about oil additives, LOLFuel additives do work - Seafoam is the best. I use it once every 20k miles.
I've found the best way to solve that is an Italian tune up followed up with spraying seafoam in the injector ports.Fuel system cleaner does a decent job of keeping fuel injectors clean if you use it regularly from basically day one. But it doesn't work magic. Adding a bottle of fuel injector cleaner to your tank won't do much for you if you've got 150k miles on your injectors and they are gummed up. The only way to reliably clean them in that case is to remove them and clean them.